2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W008216
    HMMNI
    		99.91%
    HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole (HY-B1244). Dimetridazole is a nitroimidazole class drug that combats protozoan infections.
    HMMNI
  • HY-133980A
    O-Demethyl Lenvatinib hydrochloride
    O-Demethyl Lenvatinib hydrochloride is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET. Lenvatinib shows potent antitumor activities.
    O-Demethyl Lenvatinib hydrochloride
  • HY-W017434
    3,4-Dimethylbenzoic acid
    		98.32%
    3,4-Dimethylbenzoic acid acts as a product of dimethylbenzoate metabolism by Rhodococcus rhodochrous N75.
    3,4-Dimethylbenzoic acid
  • HY-135359
    RP 48497
    		99.79%
    RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia.
    RP 48497
  • HY-W014225
    3-Phenoxybenzoic acid
    		99.81%
    3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages.
    3-Phenoxybenzoic acid
  • HY-B1398
    Ampyrone
    		99.72%
    Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy.
    Ampyrone
  • HY-N6695
    Aflatoxicol
    		99.9%
    Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp, and is mutagenic and carcinogenic mycotoxin.
    Aflatoxicol
  • HY-B1022
    Dimesna
    		≥98.0%
    Dimesna combined with anticancer chemotherapeutic agents to reduce nephrotoxicity.
    Dimesna
  • HY-13056
    SMND-309
    SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.
    SMND-309
  • HY-138627A
    AST5902 trimesylate
    		98.75%
    AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
    AST5902 trimesylate
  • HY-131964
    Imidacloprid-urea
    		99.86%
    Imidacloprid-urea is a metabolite of Imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid-urea can occupy or block adsorption sites of imidacloprid on soil, potentially affecting the fate, transport, and bioavailability of imidacloprid in the environment.
    Imidacloprid-urea
  • HY-33914
    4-Hydroxymethylpyrazole
    		99.74%
    4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase.
    4-Hydroxymethylpyrazole
  • HY-15876
    Clopidogrel thiolactone
    		≥98.0%
    Clopidogrel thiolactone is an important intermediate in the metabolism of clopidogrel (HY-15283). Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects.
    Clopidogrel thiolactone
  • HY-125643
    Pitavastatin lactone
    		99.30%
    Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes.
    Pitavastatin lactone
  • HY-W012187
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
    		99.95%
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) is a metabolite of Butylated hydroxytoluene (HY-Y0172) .
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
  • HY-118844
    Flumazenil acid
    		99.97%
    Flumazenil acid is a metabolite of Flumazenil. Flumazenil is a GABAA receptor antagonist.
    Flumazenil acid
  • HY-W004298
    10-Undecen-1-ol
    		99.56%
    10-Undecen-1-ol, converted from ricinoleic acid, can be used as a comonomer for the introduction of functional groups.
    10-Undecen-1-ol
  • HY-B1109
    N-Acetylprocainamide
    		99.89%
    N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
    N-Acetylprocainamide
  • HY-G0017S
    N-Desmethyl imatinib-d8
    		99.95%
    N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
    N-Desmethyl imatinib-d<sub>8</sub>
  • HY-B1348
    Dimethadione
    		99.93%
    Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal.
    Dimethadione
Cat. No. Product Name / Synonyms Application Reactivity